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دامنه همبندی آنتیژن
[0066] By "antigen binding domain" or "ABD" herein is meant a set of six Complementary Determining Regions (CDRs) that, when present as part of a polypeptide sequence, specifically binds a target antigen as discussed herein.
Thus, an "antigen binding domain" binds a target antigen as outlined herein.
Thus, in some cases, the six CDRs of the antigen binding domain are contributed by a variable heavy and variable light chain.
[0073] By "Fv" or "Fv fragment" or "Fv region" as used herein is meant a polypeptide that comprises the VL and VH domains of a single antigen binding domain (ABD).
In some cases, the invention provides bispecific antibodies that include at least one antigen binding domain as outlined herein.
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